Berberine: Tšebeliso, Melemo, Tlatsetso le Litlamorao

Berberine e na le nalane e telele ea ts'ebeliso lits'ebetsong tsa meriana ea setso, joalo kaAyurvedale meriana ea Asia Bochabela. Ke motsoako oa lik'hemik'hale o monate o tsoang ho mefuta e fapaneng ea limela, joalo ka hydrastis canadensis (goldenseal), coptis chinensis (coptis kapa goldenthread) le berberis vulgaris (barberry). Patlisiso e fana ka maikutlo a hore berberine e kanna ea ba le thepa ea antimicrobial le lithibela-mafu, hammoho le phello e ntle ho metabolism, empa liteko tse ling tsa kliniki lia hlokahala ho netefatsa melemo ena.

Berberine e kanna ea ba le melemo e mengata ea 'mele le mesebetsi ea bongaka sebeteng, liphio, pelo le boko, e ka fanang ka ts'ehetso e eketsehileng ea metabolism. Mohlala, berberine e kenya tšebetsong enzyme ea AMP-activated protein kinase, eo lipatlisiso li bonts'ang hore e thusa ho laola metabolism, tšebetso ea lisele le maemo a matla.

Berberine e sebelisoa haholo ho thusatsoekere e tlase ea mali, ho ntlafatsa bophelo bo botle ba pelo, ho fokotsa khatello ea oxidative lek'holeseterole e tlase, hammoho le liphello tsa eona tse khahlanong le letšollo, li-anti-inflammatory le tse khahlanong le kankere, ho bolela Heather Zwickey, Ph.D, moprofesa oa immunology Univesithing ea Sechaba ea Meriana ea Tlhaho Portland, Oregon.

Berberine hangata e fumaneha ka sebopeho sa capsule, empa hape e entsoe joalo ka marotholi a mahlo le li-gel bakeng sa maemo a fapaneng a ho ruruha a letlalo, mahlo kapa manonyeletso.

Limela tse ngata le litlama tse nang le berberine li 'nile tsa sebelisoa e le meriana ka lilemo tse likete, leha ho le joalo ho hlokahala lipatlisiso tse eketsehileng ho utloisisa mekhoa ea ts'ebetso ea motsoako le liphello tsa nako e telele. Ha ho se ho boletsoe, liphuputso li bontša hore e ka tsoela motho molemo ka litsela tse ngata.

E ka thusa ho theola tsoekere ea mali le ho thibela ho hanyetsa insulin

Tlhahlobo ea 2022 hoLimolek'hulee bontša hore berberine e ka thusamaemo a tlase a tsoekere ea malihobane e eketsa tlhahiso ea insulin le ho ntlafatsa kutloisiso ea insulin, leha ho hlokahala lipatlisiso tse ngata ho utloisisa litlamorao tsena ka botlalo[1].

E ka Thusa ho Fokotsa Cholesterol

Lipatlisiso li bontša hore berberine e ka ba le phello e ntle hoK'holeseterole ea LDLle k'holeseterole e felletseng, leha liteko tse ling tsa bongaka li hlokahala ho utloisisa tseko ena ea bophelo bo botle ka botlalo.

E ka Ntlafatsa Bophelo bo Botle ba Pelo

Berberine e ka ba le phello e ntle liseleng tsa pelo, haholo-holo maemong a ischemia (phepelo e sa lekaneng ea mali), ka ho ntlafatsa matla a mesifa ea pelo, ho fokotsa ho ruruha, ho fokotsa khatello ea oxidative, ho theola khatello ea mali le ho eketsa phallo ea pelo.

E ka 'na ea E-ba le Litlamorao tse Khahlanong le Ho ruruha

Berberine ke alkaloid e babang e fanang ka litlamorao tse thibelang ho ruruha, ho bolela Alicia McCubbins, ngaka ea naturopathic e lulang Vancouver, Washington. Litholoana tsena li ka thusa lits'ebetso tsa metabolic ka kakaretso, joalo ka tse ka thusang ho thibela atherosclerosis, lefu la tsoekere la mofuta oa 2, botenya le mathata a pelo le methapo. Lintho tse khahlanong le ho ruruha tsa Berberine li 'nile tsa ithutoa ka nako e telele, empa mokhoa oa eona oa ts'ebetso ha o e-s'o utloisisehe, o totobatsa tlhokahalo ea lipatlisiso tse eketsehileng.

E ka ba le Lintho tsa Antioxidant

Tlhahlobo ea 2018 kaMeeli ho Pharmacologye etsa qeto ea hore litlamorao tsa berberine tsa antioxidant li tšoana le tsa vithamine C, antioxidant e matla haholo[2]. Lintho tse kang vithamine C le berberine li sebetsa joalo ka li-antioxidants ho thusa ho qoba tšenyo ea li-radicals tsa mahala tse ka bakang liseleng.

E ka ba le Lintho tsa Antibacterial le Antimicrobial

"Berberine e na le thepa ea astringent 'me e nkoa e le antimicrobial ea tlhaho e nang le bokhoni ba ho leleka libaktheria, likokoana-hloko le li-fungus / candida," ho arolelana Dr. McCubbins. Lintho tsena tsa antimicrobial li ka thusa ho ntlafatsa maemo a itseng, joalo ka a hlobaetsangletšollo, letšollo, lefu la nyooko le mafu a ka botšehaling, le hoja ho hlokahala lipatlisiso tse eketsehileng ho tšehetsa lipolelo tsena. Haeba motho a lumela hore o na le tšoaetso ea baktheria ea mofuta ofe kapa ofe, o lokela ho buisana le mofani oa tlhokomelo ea bophelo bakeng sa tlhahlobo e nepahetseng le phekolo pele a nka berberine kapa tlatsetso efe kapa efe.

E ka Ntlafatsa Bophelo bo Botle ba Tšhilo ea Lijo

Berberine e ka 'na ea rua molemo ka mathata a tšilo ea lijo, joalo ka ho patoa leho nyekeloa ke pelo, ho latela Dr. McCubbins. "Li-alkaloids tsena li ka fana ka melemo e ts'episang ho khokahanyo ea mala le boko," o phaella ka ho hatisa bohlokoa ba kamano pakeng tsa tšilo ea lijo, maikutlo le bophelo bo botle ka kakaretso.

E ka Tšehetsa Taolo ea Boima le Boima ba Boima

Berberine e ka thusa ho fokotsa polokelo ea mafura le tsoekere ka ho ntlafatsa ts'ebetso ea metabolism, joalo ka ho senyeha ha lipids (mafura) le tsoekere, lipatlisiso li fana ka maikutlo. Tšusumetso e ntle ea Berberines ho microbiome ea mala le eona e ka ba karolo ea bohlokoa ts'ehetsong ea eona ea taolo ea boima ba 'mele.

E ka Ntlafatsa Matšoao a Polycystic Ovarian Syndrome (PCOS) le Ovulation

Ho latela tlhahlobo kaLimolek'hule, ho nka limiligrama tse 1,500 tsa berberine ka letsatsi ka likhoeli tse tharo ho fokolitse maemo a phahameng a testosterone ho basali ba nang lePCOS[3]. Boemo bona bo ka kenyelletsa maemo a sa tloaelehang a li-hormone tsa ho ikatisa 'me tsa baka ho se leka-lekane, ho lebisang litabeng tse kang li-cysts tse mae a bomme kapa ho ea khoeling ho sa tloaelehang. Litsebi li boetse li lumela hore berberine e ntlafatsa ho hanyetsa insulin, e leng tšobotsi e tloaelehileng ea PCOS. Leha ho le joalo, bafuputsi ba fana ka maikutlo a hore liteko tse ling tsa kliniki lia hlokahala ho netefatsa phello ena ea berberine, ho kenyelletsa bolelele ba kalafo le dosing ea kalafo.

 

Joang ho nka Berberine?

Li-supplement tsa Berberine li fumaneha ka capsule, tablet kapa foromo ea tincture, e lumellang hore ho be le litekanyetso tse nepahetseng le tšebeliso e bonolo. Li-capsules li ka 'na tsa e-ba molemo ho bareki ba bangata ho latela tatso ea eona e babang haholo, ho hlalosa Dr. McCubbins. "Berberine hangata e nkuoa e le tonic ea tšilo ea lijo metsotso e 5 ho isa ho e 30 pele ho lijo. Berberine e baba ka tlhaho e susumetsang lero la ka mpeng bakeng sa tšilo ea lijo e sebetsang hantle haholoanyane, "o tsoela pele.

Tekanyetso ea Berberine

Batho ka bomong ba lokela ho buisana le mofani oa tlhokomelo ea bophelo kapa setsebi sa litlama ho buisana ka tekanyo e nepahetseng (e sa tloaelehang), 'me ba bale litaelo tsa moetsi, ho bolela Dr. Zwickey. "Hangata ho nkoa e sireletsehile litekanyetsong tsa [letsatsi le letsatsi] tsa [tse sa feteng] ligrama tse 2. Ho [ho fihlela liphetho tse nepahetseng], motho a ka batla ho sebelisa bonyane gram e le 1 (1000 milligrams) ka letsatsi. Bongata ba li-supplement [li na le] li-milligrams tse 500 ka capsule, kahoo motho a ka batla ho noa [bonyane li-capsules tse peli] ka letsatsi,” o tsoela pele.

Tekanyetso ea Berberine e ka ipapisa le sepheo sa bophelo ba motho. Mabapi le tsoekere ea mali, tlhahlobo e hlophisitsoeng ea 2019 le tlhahlobo ea meta hoEndocrine JournalHo fumanoe ho noa ka tlase ho ligrama tse 2 tsa berberine ka letsatsi bakeng sa likhoeli tse tharo ho na le phello e ntle ho boemo ba tsoekere ea mali ho barupeluoa ba nang le lefu la tsoekere la mofuta oa 2.[4].

Ho sa le joalo, tlhahlobo ea lipatlisiso tse fumanehang hoLiphekolo tse Tlatselletsang Boikoetlisong ba Tlelinikie ile ea hlahloba karabelo ea lethal dose ea berberine extract bakeng sa batho ba nang le botenya le ho batla taolo ea boima ba 'mele, ea fumana hore litekanyetso tsa 500 milligrams tse nkiloeng hararo ka letsatsi li lebisitse ho fokotsehaindex ea boima ba 'mele (BMI), ho potoloha letheka le boima ba 'mele[5].

Litla-morao tsa Berberine

Li-supplement tsa Berberine li ka ba le litla-morao tse ling, ho kenyelletsa le letšollo, ho ferekana ka mpeng le hlooho, ho bolela Dr. McCubbins.

"Berberine e ntse e eketseha ka botumo 'me e rekisoa haholo ho sechaba sa tahlehelo ea boima ba' mele," o tsoela pele. "E-ba hlokolosi 'me u buisane le ngaka ea naturopathic mabapi le tšebeliso ea phekolo [ea berberine pele u e sebelisa]."

Le hoja berberine e atisa ho mamelloa hantle, e ka 'na ea baka bohloko ba mpeng le ho senya, ho pata, letšollo, flatulence, ho nyekeloa ke pelo le ho hlatsa, ho phaella Dr. Zwickey.

Na Berberine e Sireletsehile?

Ntho e ka sehloohong e amehang ka polokeho ea berberine ke hore e ka sebelisana le meriana e mengata, ho bolela Dr. Zwickey. Tšebelisano e matla ka ho fetisisa e ka bang teng ke cyclosporine, sethethefatsi sa immunosuppressive se sebelisoang kamora ho fetisoa ha setho le ho thusa ho laola maemo a autoimmune joalo ka.lefu la ramatiki, ha berberine e eketsa bongata ba cyclosporine maling, oa hlalosa.

Ho sa tsotellehe hore na motho o nka berberine e le tlatsetso e ntšitsoeng e ikemetseng kapa ka mokhoa o feletseng oa litlama, ho bohlokoa ho latela litaelo tse khothalletsoang tsa tekanyo e fanoeng ke moetsi oa sehlahisoa kapa setsebi sa tlhokomelo ea bophelo. Berberine e thibetsoe bakeng sa bana, hammoho le bakhachane le ba anyesang, ho bolela Dr. Zwickey.

Seo u ka se nahanang ha u reka Berberine?

Hobane bahlahisi ba bangata ba hloekisa berberine semeleng, tlhahlobo ea laboratori ea motho oa boraro bakeng sa boitsebahatso ba berberine, matla, boleng le bohloeki ke tsa bohlokoa, ho bolela Dr. Zwickey. Dr. McCubbins o phaella ka ho re: "Motho o lokela ho ba ka ho khetheha haholo mabapi le ho fumana tlatsetso ho tsoa k'hamphaning ea tlatsetso ea boemo ba bongaka ho etsa bonnete ba tlhahlobo ea mokha oa boraro ho tsoa ho lik'hamphani tse tsebahalang le netefatso ea boleng bakeng sa taolo e ntle ea [dosing]," ho phaella Dr. McCubbins.

Ho bohlokoa hape ho netefatsa hore berberine e fumaneha ka mokhoa o tsitsitseng, ho latela Dr. McCubbins. "Goldenseal, le hoja e le mohloli o babatsehang oa berberine, e kotsing. Likhamphani tsa tlatsetso tse tsebahalang li tseba ka [taba] ena,” oa hlalosa. Li-labels tse ngata tsa tlatsetso li totobatsa hore na berberine e ntšoa litlama life.

Kaha berberine e haelloa ke lithuto tsa nako e telele tsa polokeho, motho o lokela ho buisana le mofani oa tlhokomelo ea bophelo pele a eketsa berberine ho mofuta oa bona oa tlatsetso ho netefatsa hore e nepahetse ebile e bolokehile bakeng sa litlhoko tsa bona tse ikhethang tsa bophelo. Ho ithuta haholoanyane ka melemo e ka bang teng ea bophelo bo botle ba berberine, bua le ngaka ea naturopathic, setsebi sa litlama se netefalitsoeng kapa setsebi sa acupunctur.